eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2022-09-18 10 9 230 234 10.12691/ajmcr-10-9-5 AJMCR20221095 article Oadi N. Shrateh oadi.shrateh@students.alquds.edu 1 Hashem M. Khdour 1 Duha Y. Jawaada 2 Haneen Owienah 3 Thaer Sweileh 3 Samer Barahmeh 4 Ahmad Al-Sarahneh 4 Faculty of Medicine, Al-Quds University, Jerusalem, Palestine Department of Obstetrics and Gynecology, AL-Makassed Charitable Society Hospital, East Jerusalem, Palestine Radiology Department, Al-Istishari Arab Hospital, Ramallah, West Bank, Palestine Department of Obstetrics and Gynecology, Al-Istishari Arab Hospital, Ramallah, Palestine Objective: Cerebral venous sinus thrombosis (CVST) is an uncommon but serious sequalae of severe hyperemesis gravidarum. Pregnancy and puerperium are important risk factors for CVST. Here, we report a case of CVST induced by hyperemesis gravidarum. Case report: A 25-year-old Palestinian woman, gravida 3, para 2 in the first trimester of her pregnancy. The patient was first diagnosed with severe hyperemesis gravidarum due to recurrent episodes of nausea and vomiting. As the condition advanced, the patient had headache and generalized weakness for a one-week duration. Neuroimaging revealed extensive thrombosis in the cerebral sinuses; thereby CVST was diagnosed. The patient was treated with anticoagulant and had a complete recovery. Conclusion: Although rare, it is important to include cerebral venous sinus thrombosis (CVST) in the differential diagnosis of any brain syndrome during all trimesters of pregnancy and puerperium. In this case study, we affirm the significance of suspecting CVST in pregnant women complaining of any neurological syndrome, especially in the setting of severe hyperemesis gravidarum. http://pubs.sciepub.com/ajmcr/10/9/5/ajmcr-10-9-5.pdf cerebral venous sins thrombosis severe hyperemesis gravidarum pregnancy puerperium neuroimaging anticoagulation