eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2022-05-05 10 5 128 130 10.12691/ajmcr-10-5-3 AJMCR20221053 article Shruti Jesani jesanishruti@gmail.com 1 Chidinma Ejikeme 1 Sherif El Kattawy 1 Jesus Romero 1 Department of Internal Medicine, Trinitas Regional Medical Center, Elizabeth, NJ, USA Marijuana is one of the most commonly used psychotropic drugs in the United States. Recent legalization of cannabis and decriminalization in multiple jurisdictions in the United States has contributed to its increased availability and social acceptance, especially in young adults. The overall prevalence of cardiovascular disease in young adults has been increasing as a consequence of marijuana use. However, there remains a paucity of knowledge on its adverse effects, especially with regards to the cardiovascular system. Here, we present a case of a young adult with a history of marijuana use and minimal cardiovascular risk factors who presents following a seizure episode and was found to have coronary artery thrombosis. A high degree of suspicion, along with a better understanding of the biochemical pathways involved in cannabis associated myocardial ischemia is extremely important to treat this condition promptly and prevent fatal outcomes. After the legalization of cannabis in various states in the United States, there is an increasing need to understand and educate the public regarding health hazards, especially on the cardiovascular system. http://pubs.sciepub.com/ajmcr/10/5/3/ajmcr-10-5-3.pdf coronary artery thrombosis cannabis cardiovascular risks marijuana