eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2022-05-27 10 5 160 162 10.12691/ajmcr-10-5-10 AJMCR202210510 article Shujaa Faryad shujaafaryad@gmail.com 1 Habiba Hussain 1 Mawwra Faryad 2 Subramanyam Chittivelu 2 Department of Pulmonary & Critical Care Medicine, University of Illinois College of Medicine at Peoria, Peoria, USA Department of Pulmonary Medicine, Mayo Hospital, Lahore, Pakistan Cutaneous blastomycosis is the second most common presentation of Blastomyces Dermatitidis infection. Commonly, skin involvement results from hematogenous spread of infection from a distant site but direct skin involvement can also occur from trauma and animal scratch or bite resulting in cutaneous inoculation blastomycosis. Clinical features of cutaneous blastomycosis are nonspecific and overlap with other fungal and bacterial infections and skin malignancies. A high degree of suspicion is required for diagnosis while evaluating a patient with recurrent skin lesions not responding to antibiotics. In these cases, fungal cultures and histology are of paramount importance for prompt diagnosis and treatment. We present a case of primary cutaneous blastomycosis with secondary lung involvement. http://pubs.sciepub.com/ajmcr/10/5/10/ajmcr-10-5-10.pdf skin infection endemic fungi fungal infection Cutaneous Blastomycosis lung infection disseminated infection