eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2022-03-15 10 3 59 63 10.12691/ajmcr-10-3-5 AJMCR20221035 article Nishant Gaba 1 Khurshid A Mattoo drkamattoo@rediffmail.com 2 Shahad Daghiri 2 Department of Prosthetic Dentistry, Inderprastha Dental College and Hospital, CCSU, Uttar Pradesh, India Department of Prosthetic Dental Sciences, College of Dentistry, Jazan University, KSA It has been more than eight decades since the introduction of polymethylmethacrylate (PMMA) in prosthetic dentistry. Despite so many advances in material science, the use of PMMA is unabated. Its ability to be molded into desired shape and biocompatibility, are significant for its success. Certain clinical conditions do however contraindicate its uses in prosthesis, and pave way for base metal alloy denture bases. These conditions are so common, yet they are missed clinically by even most astute clinicians. This case series in the form of multiple case reports provides the reader a glance into the clinical indications for metal denture bases in complete denture prosthodontics. Each case has been explained on the basis of its particular indication. The advantages and disadvantages of metal denture bases in such situations has been discussed. A case of menopause, sorption related denture changes, need for improving oral stereognostic ability and cases where poor adaptation of denture base acrylic is inevitable are key description of this article. http://pubs.sciepub.com/ajmcr/10/3/5/ajmcr-10-3-5.pdf complete denture base metal alloys denture base major connector polymethylmetacrylate