eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2022-03-11 10 3 56 58 10.12691/ajmcr-10-3-4 AJMCR20221034 article Sabina Kumar sabina.kumar@kpc.health 1 Umeh Chukwuemeka 1 John Carvalho 1 Laura Tuscher 2 Sobiga Ranchithan 3 Rakesh Gupta 3 Chawki Harfouch 3 Pranav Barve 3 Sumanta Chaudhuri 3 Department of Internal Medicine, Hemet Global Medical Center, Hemet, California, USA Divison of Medicine, St. George¡¯s University, School of Medicine, West Indies, Grenada Division of Medicine, American University of Antigua, Osbourn, Antigua & Barbuda Multisystem inflammatory syndrome in children (MIS-C) is one of several severe complications of COVID-19 seen in children. The United States Center for Disease Control diagnostic guidelines for MIS-C include age <21 years, 24-hour history of fever ¡İ38.0ºC, severe illness necessitating hospitalization, two or more organ system involvement, laboratory evidence of inflammation, laboratory or epidemiologic evidence of SARS-CoV-2, and a lack of alternative diagnosis. This case report focuses on one patient who met six out of the seven cardinal features of MIS-C but fell outside the average age range. Unfortunately, the patient died from complications of COVID-19. Since our patient had multiple risk factors, including obesity and Hispanic ethnicity the pathogenesis of the disease occurring in our patient was likely identical to that which occurs in MIS-C. Due to a significant chance of mortality in patients with MIS-C and COVID-19, it is important to consider this diagnosis in older adolescents and young adults. This patient¡¯s unfortunate outcome urges prompt greater suspicion for this rare and life-threatening complication, even though this patient is older than the typical MIS-C patient. http://pubs.sciepub.com/ajmcr/10/3/4/ajmcr-10-3-4.pdf COVID-19 MIS-C SARS-CoV-2 Multisystem Inflammatory Syndrome in Children