eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2022-01-11 10 2 22 25 10.12691/ajmcr-10-2-1 AJMCR20221021 article Carlos E. Gonzalez carloseugenio_00@hotmail.com 1 Luis A. Gonzalez 1 Luis A. Cesenas 2 Olga G. Cantu 3 Departamento de Medicina Interna, Hospital Universitario ¡°Jos¨¦ E. Gonz¨¢lez¡±, Monterrey, M¨¦xico Departamento de Patolog¨ªa, Hospital Universitario ¡°Jos¨¦ E. Gonz¨¢lez¡±, Monterrey, M¨¦xico Departamento de Hematolog¨ªa, Hospital Universitario ¡°Jos¨¦ E. Gonz¨¢lez¡±, Monterrey, M¨¦xico Thrombotic Microangiopathy (TMA) has been described as a rare paraneoplastic syndrome. We present a patient with Coombs-negative hemolytic anemia and schistocytes in a peripheral blood smear, fulfilling diagnosis criteria for TMA. After patients death, an autopsy report revealed bone infiltrating signet ring cell carcinoma, identifying the lung as the primary tumor origin. http://pubs.sciepub.com/ajmcr/10/2/1/ajmcr-10-2-1.pdf Thrombotic microangiopathy microangiopathic hemolytic anemia signet ring cell carcinoma paraneoplastic syndrome lung cancer