eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2022-12-15 10 12 311 313 10.12691/ajmcr-10-12-4 AJMCR202210124 article Alejandro Vega B.A. Alejandro.vega@downstate.edu 1 Ernie Yap MD 1 State University of New York Medical Center, Brooklyn, NY 11203, USA Curcumin is an herbal supplement that is consumed for its purported anti-inflammatory, antioxidant, and antitumor properties as well as the prevention of gallstone formation. There have been few studies that investigate its role in people with current or history of biliary obstruction. Herein we discuss an encounter of a patient who presented with a perforated gallbladder after having ingested 1500-2250mg of curcumin per day for four months. We shall also review the state of known literature on the pharmacokinetic and pharmacodynamic profile of curcumin and its role as an herbal supplement. Lastly, we will examine the pitfalls of taking high levels of herbal supplements. http://pubs.sciepub.com/ajmcr/10/12/4/ajmcr-10-12-4.pdf Curcumin adverse events biliary obstruction gallstone perforation