eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2022-11-20 10 11 286 290 10.12691/ajmcr-10-11-2 AJMCR202210112 article Vamsidhar Vennamaneni 1 Raul Fernandez rishbhad@larkinhospital.com 1 Rishbha Dua 1 George Michel 1 Virendrasinh Ravat 1 George Yatzkan 1 Department of Internal Medicine, Larkin Community Hospital, 7031 SW 62nd Ave, South Miami, FL 33143 Bronchiolitis Obliterans Organizing Pneumonia (BOOP), also known as Cryptogenic Organizing Pneumonia, is an uncommon disease defined as an inflammation of the bronchioles which resembles pneumonia on imaging but it is in fact non-infectious pneumonia. BOOP associated with Temozolomide has been observed in a few patients and documented very little, hence, internists and oncologists at the frontier of care must be aware of this lung damage. Here we present a case of a 67-year-old patient who presents with bronchiolitis obliterans organizing pneumonia after receiving chemotherapy for Glioblastoma Multiforme with Temozolomide. When discovering the trigger for the illness was Temozolomide, it was promptly discontinued, and treatment with methylprednisolone was promptly initiated, which provided significant improvement. http://pubs.sciepub.com/ajmcr/10/11/2/ajmcr-10-11-2.pdf Bronchiolitis Obliterans Organizing Pneumonia (BOOP) cryptogenic organizing pneumonia non-infectious pneumonia Temozolomide Glioblastoma Multiforme