eng Science and Education Publishing American Journal of Medical and Biological Research 2328-4099 2021-09-13 9 1 5 9 10.12691/ajmbr-9-1-2 AJMBR2021912 article Amit Kumar Pramanik amit34th@gmail.com 1 Shihab Md. Rezoyanur Rahman 2 Kaniz Fatema 3 Mohammad Monzurul Alam Bhuiyan 4 Sheuly Ferdoushi 4 Mst. Shaila Yesmin 4 Md. Saiful Islam 4 Md. Quddusur Rahman 4 Shaikh Nafia Sultana 5 Debatosh Paul 5 Department of Transfusion Medicine, Rajshahi Medical College Hospital, Rajshahi, Bangladesh Gaibandha General Hospital, Gaibandha, Bangladesh Sheikh Hasina National Institute of Burn and Plastic Surgery, Dhaka, Bangladesh Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh Department of Urology, United Hospital, Dhaka, Bangladesh Historically, High level of serum testosterone was thought to have deleterious effect on cardiovascular system. In the last few years, studies have suggested that low testosterone levels are associated with increase prevalence of risk factors for cardiovascular diseases. This study aimed to determine the relationship between free testosterone level and the angiographic severity of coronary artery disease in young adult male patients. This cross-sectional study was conducted at Department of Laboratory Medicine in collaboration with Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU) and National Institute of Cardiovascular Diseases (NICVD), Dhaka, Bangladesh from March, 2020 to February, 2021. Total 110 subjects from inpatient Department of Cardiology were enrolled, 60 were CAD patients and 50 were Normal Coronaries according to coronary angiography report. Serum level of free testosterone was significantly lower in CAD group than Normal coronaries (4.74±2.10 vs 9.36±3.69 pg/ml, p=0.001). There were significant negative correlation between free testosterone with Gensini score (r= -0.739, p=0.001). Low level of free testosterone was negatively correlated with CAD and its severity in young adult male. http://pubs.sciepub.com/ajmbr/9/1/2/ajmbr-9-1-2.pdf Coronary artery diseases Gensini score free testosterone young adult male