eng Science and Education Publishing American Journal of Medical and Biological Research 2328-4099 2015-08-05 3 5 128 132 10.12691/ajmbr-3-5-2 AJMBR2015352 article Zuzana Guľašová gulasova.z@gmail.com 1 Vladimíra Tomečková 1 Miroslava Bilecová-Rabajdová 1 Beáta Veliká 1 Panayotis Artemiou 2 Vladimír Komanický 3 Mária Mareková 3 Department of Medical and Clinical Biochemistry, Pavol Jozef Šafárik University, Faculty of Medicine, Košice, Slovakia Department of Cardiovascular Surgery, Pavol Jozef Šafárik University, Faculty of Medicine and VUSCH, Košice, Slovakia Institute of Physics, Pavol Jozef Šafárik University, Faculty of Science, Košice, Slovakia Components of the blood plasma and serum represent a mixture of various endogenous substances with fluorescence properties. The aim of this work was a detection of pathological changes in blood of patients with thoracic aortic aneurysm by fluorescence spectroscopy and atomic force microscopy. The resulting autofluorescence of fluorophores in blood of patients with thoracic aortic aneurysm decreased in comparison with healthy subjects. The structure of the thoracic aorta was changed during the thoracic aortic aneurysm, what was manifested as the structural modifications in blood of patients observed by using atomic force microscopy. The fluorescence analysis and atomic force microscopy present new experimental ways in the study of the thoracic aortic aneurysm. http://pubs.sciepub.com/ajmbr/3/5/2/ajmbr-3-5-2.pdf thoracic aortic aneurysm fluorescence spectroscopy blood plasma and serum