@article{ajmbr2015311,
author={{Masri, Niveen M. and Hanbali, Lama B. and Haddad, John J.},
title={The Immunomodulatory, Antimicrobial and Bactericidal Efficacy of Commonly Used Commercial Household Disinfectants, Sterilizers and Antiseptics in Vitro: Laboratory Assessment of Anti-Inflammatory Infection Control Mechanisms and Comparative Biochemical Analysis of the Microbial Growth of Gram-Negative Bacteria},
journal={American Journal of Medical and Biological Research},
volume={3},
number={1},
pages={1--32},
year={2015},
url={http://pubs.sciepub.com/ajmbr/3/1/1},
issn={2328-4099},
abstract={Background: Immunomodulatory/anti-inflammatory and microbial infection control strategies characterize the spiral evolution of public awareness of health safety issues. This is substantiated with burgeoning number of cases of microbial contamination and/or infection in myriad healthcare settings, at the hospital, and even at home. Previously, we have investigated and identified laboratory parameters in the assessment of the antimicrobial effects of a myriad of commercial disinfectants on the growth of pathogenic and saprophytic gram-positive bacteria. The present sequel study investigates the antimicrobial/bactericidal effects of commercially available disinfectants, sterilizers, antiseptics, and chlorhexidine-containing detergents on the growth of saprophytic and pathogenic gram-negative bacteria in vitro. It is an unprecedented wide canopy enveloping standardized comparative assessments of the antimicrobial efficiency of consumer-targeted household detergents, curbing and containing microbial infection, inflammation and contamination propensity. Methods: Given the medical significance and impact of public infection control, we have meticulously examined at least 22 different detergents categorized into four classes (each category comprises a variety of commercially available products commonly used by the public): i) Class A ¨C Daily Mouthwash; ii) Class B ¨C Toilet Bowl Cleaners/Bleaches/Sanitizers; iii) Class C ¨C Surface and Floor Mopping Cleaners/Detergents; and iv) Class D ¨C Hand and Body Wash Gels. Whilst the canonical menu of active ingredients varies among those aforementioned classes, antimicrobial components are well established. Results: Regarding Class A, the most effective against Citrobacter koseri is ¡®Colgate Plax Mouthwash¡¯; Enterobacter cloacae is ¡®Colgate Plax Mouthwash¡¯; Escherichia coli is ¡®Colgate Plax Mouthwash¡¯; Escherichia coli ESBL is ¡®Colgate Plax Mouthwash¡¯; Klebsiella pneumoniae is ¡®Colgate Plax Mouthwash¡¯; Proteus vulgaris is ¡®Colgate Plax Mouthwash¡¯; Pseudomonas aeruginosa is ¡®Perio.Kin Chlorhexidina 0.20 %¡¯; Salmonella typhimurium is ¡®Colgate Plax Mouthwash¡¯; and Shigella sonnei is ¡®Colgate Plax Mouthwash¡¯. Regarding Class B, the most effective against C. koseri is ¡®Harpic Power Plus Disinfectant¡¯; E. cloacae is ¡®WC Net Bleach Gel¡¯; E. coli is ¡®WC Net Bleach Gel¡¯; E. coli ESBL is ¡®WC Net Bleach Gel¡¯; K. pneumoniae are ¡®WC Net Bleach Gel¡¯ and ¡®Harpic Power Plus Disinfectant¡¯; P. vulgaris is ¡®Spartan Max WC Lavender¡¯; P. aeruginosa is ¡®WC Net Bleach Gel¡¯; S. typhimurium is ¡®Clorox Bleach Rain Clean¡¯; and S. sonnei is ¡®Harpic Power Plus Disinfectant¡¯. Regarding Class C, the most effective against C. koseri is ¡®Dettol Antiseptic/Disinfectant¡¯; E. cloacae is ¡®Dettol Antiseptic/Disinfectant¡¯; E. coli is ¡®Vim Cream Multipurpose Fast Rinsing¡¯; E. coli ESBL is ¡®Dettol Antiseptic/Disinfectant¡¯; K. pneumoniae is ¡®Dettol Antiseptic/Disinfectant¡¯; P. vulgaris is ¡®Dettol Antiseptic/Disinfectant¡¯; P. aeruginosa is ¡®Dettol Antiseptic/Disinfectant¡¯; S. typhimurium is ¡®Dettol Antiseptic/Disinfectant¡¯; and S. sonnei is ¡®Dettol Antiseptic/Disinfectant¡¯. Regarding Class D, the most effective against C. koseri, E. cloacae, E. coli, E. coli ESBL, K. pneumoniae, P. vulgaris, P. aeruginosa, S. typhimurium, and S. sonnei is unprecedentedly the ¡®HiGeen Hand and Body Wash Gel¡¯. Conclusions: These laboratory results emphatically confirm and verify immunomodulatory infection control variations in the antimicrobial/anti-inflammatory effectiveness of household antiseptics and disinfectants that are purportedly identified in ameliorating the growth of saprophytic and pathogenic gram-negative bacteria in culture.},
doi={10.12691/ajmbr-3-1-1}
publisher={Science and Education Publishing}
}