eng Science and Education Publishing American Journal of Medical and Biological Research 2328-4099 2014-12-28 2 6 124 127 10.12691/ajmbr-2-6-2 AJMBR2014262 article Mohammad Saleem saleem2978@hotmail.com 1 Faiza Naseer 1 Sohail Ahmad 2 Attiya Nazish 2 Fiza Raza Bukhari 2 Atta Ur Rehman 2 Imran Mahmood Khan 3 Samra Sadiq 3 Fatima Javed 3 College of Pharmacy, GC University, Faisalabad, Pakistan Department of Biochemistry, Hazara University, Mansehra, KPK, Pakistan Department of Pharmacology, Independent University Hospital, Faisalabad, Pakistan The hepatoprotective activity of Conyza bonariensis ethanol extract was studied against paracetamol induced hepatotoxicity in mice. The results showed that an extract of C.B (250 mg/kg and 500 mg/kg) produced (p<0.05) decline in paracetamol induced liver marker enzymes and total bilirubin, but its 750 mg/kg showed remarkable decline in ALT, AST, ALP and TB levels, compared to the reference levels of silymarin and results were supported by histopathology of liver section. So, it is concluded that 750 mg/kg is highly potent dose of ethanol extract of Conyza bonariensis and this potential may be due to the presence of the active constituent: qurecetin and chromatogram by HPLC confirmed its presence. http://pubs.sciepub.com/ajmbr/2/6/2/ajmbr-2-6-2.pdf Conyza bonariensis hepatoprotective Paracetamol