@article{ajmbr2014232,
author={{EL-Refai, Abeer A. and Fatani, Sameer H. and Kamel, Hala F. M.},
title={Association of Adipocytokines: Resistin and Retinol Binding Protein-4 with Severity of Preeclampsia and Insulin Resistance},
journal={American Journal of Medical and Biological Research},
volume={2},
number={3},
pages={76--82},
year={2014},
url={http://pubs.sciepub.com/ajmbr/2/3/2},
issn={2328-4099},
abstract={Dysregulation of maternal circulating adipocytokines has been implicated in several obstetrical syndromes including preeclampsia (PE). It has been suggested that adipocytokines provide a molecular link between metabolic derangements and inflammatory response in complicated pregnancies. We aimed in this study to evaluate the relationship between serum levels of Retinol binding protein-4 (RBP-4) and Resistin with clinical, anthropometric and metabolic parameters of PE. <b>This study included 3 groups:</b> group 1 included 50 pregnant females with PE, group 2 included 50 healthy pregnant females and group 3 included 50 healthy non-pregnant female as a control group. For all groups anthropometric and clinical measurements were performed. Serum RBP-4, resistin, insulin were measured by ELISA and Insulin resistance was calculated by Hemostasis model assessment index (HOMA-IR). Our results showed that serum RBP-4 and resistin concentrations were elevated in PE [39(33.25-40.87) ug/ml] &amp; [61(23.5-91.87) ng/ml] compared to normal pregnancy [18.5(8-27.87) ug/ml] &amp; [25.5(12.7-49.12) ng/ml). Moreover, RBP4 but not resistin levels were elevated in severe cases relative to mild cases of PE. Serum levels of RBP4 showed positive significant correlation with [SBP (r=0.38, p= 0.001) &amp; DBP (r=0.32, p=0.01)] which are markers of severity. Fasting insulin was positively correlated with RBP-4 (p=0.04). By multiple linear regression analysis, serum RBP-4 levels were significantly and positively correlated with SBP (P=0.01), while markers of adiposity were not independently associated with resistin. <b>Conclusion:</b> RBP-4 and resistin were up-regulated in PE, furthermore RBP-4 not resistin levels were independently associated with markers of severity of PE. However no clear relationship were observed between HOMA-IR with both RBP-4 and resistin and the role of Insulin resistance in PE was not clearly proved.},
doi={10.12691/ajmbr-2-3-2}
publisher={Science and Education Publishing}
}