Science and Education Publishing American Journal of Medical and Biological Research 2328-4099 2 3 2014 05 23 Seroprevalence of Cytomegalovirus (CMV) among Blood Donors at Bowen University Teaching Hospital Ogbomoso 72 75 EN Oladipo E.K. Department of Pure and Applied Biology (Microbiology / Virology Unit), Ladoke Akintola University of Technology, Ogbomoso, Nigeria Akinpelu O.O. Oladipo A.A. Edowhorhu G. AJMBR2014231 10.12691/ajmbr-2-3-1 2014 01 02 2014 01 30 2014 05 23 This study was designed to determine the seroprevalence of Cytomegalovirus (CMV) among blood donors at Bowen University Teaching Hospital (BUTH), Ogbomoso, Oyo State, Nigeria. Three hundred (300) consenting potential blood donors were recruited between April and September, 2012 into the study. Each subject was screened for HIV, HBsAg and HCV and structured questionnaire was administered. A total of 93(male = 63; Female = 30) subjects with mean age of 45±2.3 years previously tested negative to HIV, HBsAg and HCV were screened for CMV using Enzyme Linked Immunosorbent Assay (ELISA). Twenty-six (28.0%) were positive for anti-CMV IgM and Twenty-four (25.8%) were positive for anti- CMV IgG. The prevalence of anti- CMV IgM was highest in the age range 18-24 (45.5%), female (43.3%), single (31.4%), student (37.8%), and donors who have not been transfused (27.8%). The prevalence of anti- CMV IgG was highest in the age range 18-24 (39.4%), female (35.1%), single (25.5%), student (35.1%), and donors who have not been transfused (25.6%). The IgG+IgM- has a mean value of 3.0 which is significantly different from that of IgG-IgM+ antibody with a mean value of 5.0 These results provide more and further evidence that cytomegalovirus is present among blood donors at BUTH, and that immunocompromised individual that has been transfused with the infected blood or blood products are at risk of been infected with the virus. This also confirms that the virus spreads through blood transfusion.