Science and Education Publishing American Journal of Medical and Biological Research 1 4 2013 12 24 Complicated Skin and Skin Structure Infections (cSSSI's): A Comprehensive Review 159 164 EN K V Ramana Department of Microbiology, Prathima Institute of Medical Sciences, Karimnagar, India Venkata BharatKumar Pinnelli Bhanu Prakash Wilma Delphine Silvia CR Sabitha Kandi CH V Sharada Anand Kalaskar Sanjeev D Rao Ratna Mani Ratna Rao AJMBR2013149 10.12691/ajmbr-1-4-9 2013 02 26 2013 12 06 2013 12 24 Complicated skin and skin structure infections (cSSSI's) are among the most common microbial infections occurring both in the community and the hospitals. Aetiology of cSSSI's is complex and includes various microorganisms (bacteria, fungi, parasites and viruses). cSSSI's in general are poly microbial in nature including both anaerobic and aerobic bacterial species. Primary cSSSI's resulting from single bacterial species and secondary bacterial infections in patients suffering from skin conditions due to autoimmune conditions (eczema) or other microbial causes (viruses, fungi and parasites) have been reported in the literature. Occurrence of multi-drug resistant bacteria, underlying co-morbidities contribute to the complications in the management of cSSSI's. Formulating effective guidelines for clinical, laboratory diagnosis, treatment and management of patients suffering from cSSSI's would certainly be beneficial in the reduction of morbidity and mortality.