eng Science and Education Publishing American Journal of Medical and Biological Research 2013-12-24 1 4 159 164 10.12691/ajmbr-1-4-9 AJMBR2013149 article K V Ramana ramana_20021@rediffmail.com 1 Venkata BharatKumar Pinnelli 2 Bhanu Prakash 3 Wilma Delphine Silvia CR 4 Sabitha Kandi 5 CH V Sharada 6 Anand Kalaskar 6 Sanjeev D Rao 6 Ratna Mani 7 Ratna Rao 7 Department of Microbiology, Prathima Institute of Medical Sciences, Karimnagar, India Department of Biochemistry, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, India Department of Dermatology, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, India Department of Biochemistry, Akash Institute of Medical Sciences & Research Center, Bangalore, India Department of Biochemistry, Chalmeda Anandarao Institute of Medical Sciences, Karimnagar, India Department of Microbiology, Prime Hospitals, Hyderabad, India Department of Microbiology, Apollo Hospitals, Jubilee Hills, Hyderabad, India Complicated skin and skin structure infections (cSSSI's) are among the most common microbial infections occurring both in the community and the hospitals. Aetiology of cSSSI's is complex and includes various microorganisms (bacteria, fungi, parasites and viruses). cSSSI's in general are poly microbial in nature including both anaerobic and aerobic bacterial species. Primary cSSSI's resulting from single bacterial species and secondary bacterial infections in patients suffering from skin conditions due to autoimmune conditions (eczema) or other microbial causes (viruses, fungi and parasites) have been reported in the literature. Occurrence of multi-drug resistant bacteria, underlying co-morbidities contribute to the complications in the management of cSSSI's. Formulating effective guidelines for clinical, laboratory diagnosis, treatment and management of patients suffering from cSSSI's would certainly be beneficial in the reduction of morbidity and mortality. http://pubs.sciepub.com/ajmbr/1/4/9/ajmbr-1-4-9.pdf complicated skin and skin structure infections (cSSSI's)aetiology of cSSSI'smulti-drug resistance