@article{ajmbr2013143,
author={{Deshpande, Neelesh and Kandi, Sabitha and Kumar, P Venkata Bharath and Ramana, K V and Muddeshwar, Manohar},
title={Effect of Alcohol Consumption on Oxidative Stress Markers and its Role in the Pathogenesis and Progression of Liver Cirrhosis},
journal={American Journal of Medical and Biological Research},
volume={1},
number={4},
pages={99--102},
year={2013},
url={http://pubs.sciepub.com/ajmbr/1/4/3},
abstract={Oxidative stress has been increasingly implicated in the pathogenesis and progression of liver cirrhosis. Chronic ethanol consumption induces an oxidative stress resulting in increased ferritin levels and thereby iron over load. The study was aimed at evaluating the relation between alcohol consumption and erythrocyte superoxide dismutase (SOD), Glutathione peroxidase (GPx), Malondialdehyde (MDA) activities in liver cirrhosis patients. The study included two groups based on alcohol consumption; subjects taking low alcohol content (Less than 150 g/day.), those consuming high alcohol content (More than 150 g/day), diagnosed as suffering from liver cirrhosis and control group who do not take alcohol and are not suffering from liver cirrhosis. All cirrhotic patients on high alcohol intake in the study group had lower serum SOD (P < 0.0001), GPx (0.0001) and significantly higher MDA levels (P<0.001) than those with subjects taking low alcohol and control group. These results suggest that the decrease in erythrocyte SOD, GPx and increase in MDA levels are related to the alcohol consumption and that may be associated with pathogenesis and progression of liver disease.},
doi={10.12691/ajmbr-1-4-3}
publisher={Science and Education Publishing}
}