@article{ajidm2016432,
author={{Huang, Ian and Joey, Gregoey and Cucunawangsih, C and Tampubolon, Oloan E.},
title={The Role of APACHE-II Score in Predicting <i>Acinetobacter baumannii </i>Colonization/Infection and Its Antimicrobial Resistance Pattern in Indonesian Teaching Hospital},
journal={American Journal of Infectious Diseases and Microbiology},
volume={4},
number={3},
pages={56--60},
year={2016},
url={http://pubs.sciepub.com/ajidm/4/3/2},
issn={2328-4064},
abstract={<b>Background:</b> A first precautionary action against <i>Acinetobacter baumannii (A.baumanii) </i>can be conducted by identifying well-established risk factors of colonization/infection of that pathogen, such as underlying severity of illness. There are hardly any studies regarding the role of APACHE-II score in predicting risk of <i>A.baumannii </i>colonization/infection in Indonesia. <b>Materials and Methods:</b> A retrospective, case control investigation was performed with medical and microbiology records of ICU patients in an Indonesian Teaching Hospital from January 2013 to December 2014. <b>Results: </b>There were 39 patients with <i>A.baumannii</i> colonization/infection and 59 patients with non-<i>A.baumannii</i> colonization/infection enrolled in this study. Patients with <i>A.baumannii</i> colonization/infection had a significantly higher APACHE II score than non-<i>Acinetobacter</i> group, 25.7 and 23.1 (p=0.038), respectively. APACHE II score ¡Ý 23 had 74.4% sensitivity and 50.8 specificity<i> </i>to<i> A.baumannii</i> colonization/infection [odd ratio (OR) 3.00, 95% confidence interval (CI) 1.24-7.24, p=0.013], on the other hand APACHE II ¡Ý 27 had a 53.8% sensitivity and 78.0% specificity (OR 3.75, 95% CI 1.57-8.95, p=0.002). The highest susceptibility level of antibiotics against <i>A.baumannii</i> in this study was shown by tigecycline (82.1%) and amikacin (84.6%). <b>Conclusions:</b> APACHE-II score was strongly correlated with <i>A.baumannii</i> colonization/infection and a cut-off value of APACHE II score ¡Ý 23 may be used to depict increased moderate risk of <i>A.baumannii </i>colonization/infection. While the use carbapenem against <i>A. baumannii </i>infection was<i> </i>not recommended, tigecycline and amikacin may be considered as antibiotics of choice in treating <i>A.baumannii</i> infection in our hospital setting.},
doi={10.12691/ajidm-4-3-2}
publisher={Science and Education Publishing}
}