@article{ajidm2016415,
author={{Baiu, Saleh. H. and Al-Abdli, Nadia. E.},
title={Inducible Clindamycin Resistance in Methicillin Resistant <i>Staphylococcus</i> <i>aureus</i>},
journal={American Journal of Infectious Diseases and Microbiology},
volume={4},
number={1},
pages={25--27},
year={2016},
url={http://pubs.sciepub.com/ajidm/4/1/5},
issn={2328-4064},
abstract={The resistance to antimicrobial agents among staphylococci is an increasing problem. This has led to renewed interest in the usage of macrolide-lincosamide-streptogramin B (MLSB) antibiotics to treat <i>Staphylococcus aureus</i> infections. In vitro routine tests for clindamycin susceptibility may fail to detect inducible clindamycin resistance thus necessitating the need to detect such resistance by a simple D-test on routine basis. The objective of this study was to investigate <i>S. aureus</i> collected isolates for MLSB phenotypes, in particular inducible clindamycin resistance (MLSBi). <b>Methods:</b> Four hundred and forty six <i>S.aureus</i> isolates from samples were evaluated and inducible resistance to clindamycin was detected by D-test as per CLSI guidelines (2012). <b>Results</b>: Among 224 isolates of staphylococci studied, 101 (21.4%) were methicillin-resistant <i>S. aureus</i> (MRSA) and 123 (26.1%) were methicillin-sensitive <i>Staphylococcus aureus</i> (MSSA). Of the 224 staphylococcal isolates 62 (27.7%) were resistant to erythromycin of which 10 (4.46%) showed inducible clindamycin resistance and belonged to the MLSBi phenotype. Among the 10 MLSBi phenotype 7 (6.93%) were MRSA and 3 (2.44%) were MSSA. <b>Conclusion:</b> D-test should be included as a mandatory method in routine disc diffusion testing to detect inducible clindamycin resistance in staphylococci for the optimum treatment of patients.},
doi={10.12691/ajidm-4-1-5}
publisher={Science and Education Publishing}
}