Science and Education Publishing American Journal of Infectious Diseases and Microbiology 2328-4064 2 3 2014 06 11 Oral Tuberculosis: An Acid Fast Negative Case Report 45 47 EN Mehdi Nasr Isfahani Parichehr Ghalayani Fahimeh Pakravan Department of oral medicine, Isfahan university of medical sciences, Isfahan, Iran AJIDM2014231 10.12691/ajidm-2-3-1 2014 05 03 2014 05 24 2014 06 11 We report a rare case of tuberculosis of oral cavity in a 3.5 year-old male who was referred to oral medicine department with a chief complaint of a painless lesion in the oral cavity. Incisional biopsy from the lesion margin depicted histological features of necrotizing granulomatous lesion. Ziehl-Neelsen staining for acid fast bacilli, interestingly, was negative.