@article{ajidm20241222,
author={{Manyahilal, Abinet Tekalign and mekonnen, Dufera and Tesfaye, Amanuel Gebreselassie and Ayalew, Zekarias Seifu and Azibte, Gebeyehu Tessema and legesse, Biruk Abate and Gebremedhin, Samuel Tsehaye},
title={Left Ventricular Systolic Dysfunction in the Antiretroviral Therapy Era: A Call for Comprehensive Cardiovascular Management in People Living with HIV in Ethiopia},
journal={American Journal of Infectious Diseases and Microbiology},
volume={12},
number={2},
pages={29--36},
year={2024},
url={https://pubs.sciepub.com/ajidm/12/2/2},
issn={2328-4064},
abstract={<b>Background: </b>Access to antiretroviral therapy (ART) has transformed HIV infection into a chronic disease. However, cardiovascular disease (CVD) is now a leading cause of morbidity and mortality among people living with HIV (PLWH). This study assessed the prevalence and predictors of left ventricular systolic dysfunction (LVSD) among PLWH in Ethiopia. <b>Methods:</b> An institution-based cross-sectional study involving 156 PLWH was conducted. Medical records were reviewed, and a structured questionnaire was used to collect data on demographics, clinical characteristics, medications, and echocardiography findings. Binary logistic regression identified factors associated with LVSD (p&lt;0.05). <b>Results:</b> LVSD prevalence was 19%, with ischemic heart disease (75%) as the primary cause. Echocardiography revealed abnormalities in 40% of participants, with ischemic heart disease (16.6%) being the most frequent. Dyslipidemia (51.6%) and hypertension (30.8%) were the most common traditional risk factors. After adjusting for covariates, diabetes mellitus (AOR=14.7, p=0.009), age (AOR=12.2, p=0.073), sex (AOR=7.4, p=0.006), presence of cardiac signs (AOR=6.6, p=0.011), duration of HIV illness (p=0.005) and ART exposure (p=0.03), and stage IV HIV (AOR=8.9, p=0.008) were independent predictors of LVSD. <b>Conclusion:</b> LVSD is prevalent among PLWH in Ethiopia, with ischemic heart disease being the leading cause. Traditional risk factors and HIV-related factors contribute to LVSD. These findings highlight the need for comprehensive CVD management strategies in PLWH.},
doi={10.12691/ajidm-12-2-2}
publisher={Science and Education Publishing}
}