eng Science and Education Publishing American Journal of Infectious Diseases and Microbiology 2328-4064 2022-12-21 10 4 131 138 10.12691/ajidm-10-4-3 AJIDM20221043 article Nicole Prisca Makaya Dangui Nieko nicolemakaya@gmail.com 1 2 Cyr Jonas Morabandza 2 2 3 Mo?se Doria Kaya-Ongoto 3 3 Duchel Jeanedvi Kinouani Kinavouidi 3 3 Prosvi-Esrom Bikouma Mbangou 3 Service de Bact¨¦riologie, Laboratoire National de Sant¨¦ Publique, BP 120, Brazzaville, Congo Aminoglycosides and fluoroquinolones are among the most used antibiotics in synergy with beta-lactams. The objective of this work was to detect genes associated with resistance to fluoroquinolones and aminoglycosides in multiresistant strains of enterobacteria responsible for urinary tract infections. The diffusion method was used for antimicrobial sensitivity test of strains. qnr and aac genes were detected by Polymerase Chain Reaction. A total of 128 enterobacterial strains were studied. Resistance to the antibiotic families tested was observed with a frequency greater than 50%. Aminoglycosides were the least active family among the antibiotics used, with a resistance rate of 69.53%. aac(6¡¯)-Ib-cr and qnrS genes were detected at rates of 34.09% and 22.72%, respectively. 13.63% of the strains showed coexpression of the qnr and aac genes. The detection of resistance genes to fluoroquinolones and aminoglycosides in enterobacterial strains isolated at the National Public Health Laboratory in Brazzaville could constitute a major concern in the therapeutic management of patients because it could lead to high costs for prolonged hospitalization. http://pubs.sciepub.com/ajidm/10/4/3/ajidm-10-4-3.pdf Enterobacteriaceae multidrug resistance fluoroquinolones and aminoglycosides resistance genes urinary tract infections