eng Science and Education Publishing American Journal of Infectious Diseases and Microbiology 2328-4064 2022-04-28 10 2 88 91 10.12691/ajidm-10-2-5 AJIDM20221025 article Alassani A adebayoalassani@gmail.com 1 Mama Cisse I 1 Dovonou AC 1 Degnon G 1 Attinsounon AC 1 Wanvoegbe A 2 Gomina M 2 Faculty of Medicine of the University of Parakou, Benin Faculty of Medicine of the University of Abomey-Calavi, Benin Introduction: The COVID-19 pandemic is a real global health crisis. Despite preventive measures, the infection with SARS-CoV-2 continues to rage and has become a community epidemic. The objective of this work was to study SARS-CoV-2 infection among motorcycle taxi drivers in Parakou city in 2021. Methods: This was a descriptive and analytical cross-sectional study with prospective data collection, carried out from February 1 to March 31, 2021. It concerned the motorcycle taxi drivers of Parakou city, selected by random sampling. The variables studied were knowledge, attitude, practice towards COVID-19 and infection with SARS-CoV-2. The data processing was done with the software Epi Data analysis and Stata. Results: Of the 426 subjects surveyed, 83.57% had a good knowledge of COVID-19; however 48.59% had a good attitude and 49.30% an adequate practice toward COVID-19. Factors associated with good knowledge of SARS-CoV-2 infection were school subjects (OR = 1.92; p = 0.025) and monthly income greater than or equal to 40000F CFA (OR = 1.87; p <0.001). The factor associated with good attitude towards SARS-CoV-2 was walking more than 25 neighborhoods (OR = 0.65; p = 0.021) and the factor associated with adequate practice was age over 45 years. (OR = 0.58; p = 0.044). Among these motorcycle taxi drivers, 2 were infected with SARS-CoV-2. The prevalence of SARS-CoV-2 was 0.47%. Conclusion: Motorcycle taxi drivers have a good level of knowledge but an attitude and a practice to be improved. The prevalence of SARS-CoV-2 infection is low in this risk group. http://pubs.sciepub.com/ajidm/10/2/5/ajidm-10-2-5.pdf knowledge attitudes practices prevalence SARS-CoV-2 motorcycle taxi