@article{ajhr2013115,
author={{Rubio-Guerra, Alberto F. and Vargas-Robles, Hilda and Ayala, German Vargas and Rodriguez-Lopez, Leticia and Duran-Salgado, Montserrat B. and Escalante-Acosta, Bruno A.},
title={Serum Levels of Circulating Soluble Adhesion Molecules and Nitrites in Patients with Prehypertension},
journal={American Journal of Hypertension Research},
volume={1},
number={1},
pages={23--25},
year={2013},
url={http://pubs.sciepub.com/ajhr/1/1/5},
abstract={Endothelial dysfunction is associated with vascular inflammation, reduced serum levels of nitric oxide, vasoconstriction and atherosclerosis.Soluble adhesion molecules (SAM) are considered markers of endothelial dysfunction and play a role in end organ damage in those patients. Prehypertensive patients suffer endothelial dysfunction. <b>The aim</b> of this study was to evaluate the serum levels of circulating soluble adhesion molecules and nitric oxide (evaluated as serum levels of nitrites) in prehypertensive non-diabetic patients. <b>METHODS</b>: Circulating levels of VCAM-1, ICAM-1 and e-selectine (ELISA RyDSystems Minneapolis USA), and serum nitrite levels (Griess method, Molecular Probes Inc. Oregon USA) were measured in 20 prehypertensive non-diabetic patients (as defined by JNC 7) and in 20 age matched normotensive controls. Statistical analysis was performed with ANOVA. <b>RESULTS: </b>Prehypertensive patients showed significantly higher levels of SAM, (VCAM-1; 530 ¡À 30.9 vs. 477 ¡À 22.5 ng/ml p&lt;0.001), (ICAM-1; 285 ¡À 16.5 vs. 239 ¡À 14.9 ng/ml p&lt;0.001), (E- selectin; 68 ¡À 6.9 vs. 52 ¡À 9.8 ng/ml p&lt;0.01) and lower levels of nitrites (4.5 ¡À 0.8¦Ìmol/L vs. 6.2 ¡À 1.2 ¦Ìmol/L p&lt;0.01) than controls. <b>CONCLUSION</b>: Prehypertensive patients showed higher circulating levels of SAM and lower nitrites than normotensive subjects; which may explain why prehypertensive patients had more complications and coronary risk than normotensive patients.},
doi={10.12691/ajhr-1-1-5}
publisher={Science and Education Publishing}
}