eng Science and Education Publishing American Journal of Food and Nutrition 2374-1163 2023-10-07 11 3 89 99 10.12691/ajfn-11-3-4 AJFN20231134 article Karnon Coulibaly 1 Fatoumata Camara 1 Ekoua Regina Krabi 2 Wahauwouele Hermann Coulibaly Wahauwouele Hermann Coulibaly, wahauwouele@yahoo.fr 3 Brahima Kande 4 Koffi Cyrille Tan 4 Nutrition and Food Safety Laboratory, Food Science and Technology Formation and Research Unit (UFR-STA), Nangui Abrogoua University, 02 BP 801 Abidjan 02, Ivory Coast. UPR Biotechnology, Biosciences Formation and Research Unit, Felix Houphouet Boigny University, Abidjan, Ivory Coast Biotechnology and Food Microbiology Laboratory, Food Science and Technology, Formation and Research Unit, University Nangui Abrogoua, 02 BP 801 Abidjan 02, Ivory Coast. Botany and Plant Diversity Valorization Laboratory, Natural Sciences Formation and Research Unit (UFR-SN), Nangui Abrogoua University, 02 BP 801 Abidjan 02, Ivory Coast. In Africa, and particularly in Ivory Coast, metabolic diseases represent a public health problem. Face at this problem the prevention seems to be a suitable solution. The objective of this work was to evaluate the anti-diabetic properties and nutritional effects of different formulations made from soumbara and Moringa oleifera leaves through an animal experiment. For this purpose, ten batches of five mouse were constituted. The animals of nine batches were made diabetic by alloxane. Mouse in lot 3 were given daily doses of glibenclamide at 5 mg/Kg bw and lots 4, 5, 6 ,7,8, 9 and 10 were given the aqueous extract of the formulations at 5000 mg/Kg bw for 21 days. The blood glucose levels of the mouse were measured. At the end of the experiment, the mouses were fasted and anaesthetized with chloral and then sacrificed. Their blood was collected in dry tubes to determine their biochemical parameters. Thus, the results showed that the mouse which received by gavage the aqueous extracts of the diets particularly the formulation S20M80 and S30M70, proved to be more effective in the treatment of hyperglycemia. The observed results showed overall, an increase in body weight (2.33 to 14.33 g), serum iron level (78.25 to 96.41 ¦Ìg /mL), but also a decrease in blood glucose level (1.70 to 1.16 g/l). Based on these results, the S20M80 formulation seemed to be suitable to help prevent type 2 diabetes and reduce micronutrient deficiencies. http://pubs.sciepub.com/ajfn/11/3/4/ajfn-11-3-4.pdf Moringa leaves soumbara food formulation biochemical parameters