Science and Education Publishing American Journal of Epidemiology and Infectious Disease 2333-1275 5 1 2017 3 3 Seasonal Distribution of Dengue Fever in the Central Highlands Region, Vietnam (2010- 2015) 8 13 EN Le Van Tuan Department of Virology, Tay Nguyen Institute of Hygiene and Epidemiology, 34 Pham Hung Street, Buon Ma Thuot city, DakLak, Vietnam Nguyen Thi Tuyet Van Phan Thi Tuyet Nga Le Duong Minh Quan Pham Tho Duoc AJEID2017512 10.12691/ajeid-5-1-2 2016 11 2 2017 1 12 2017 3 1 Background: Dengue virus infection has emerged as a notable public health problem in recent decades in terms of the mortality and morbidity associated with it. Dengue has been known to be endemic in the Central Highlands region, Vietnam for over 30 years. Here we have reported the trend of Dengue fever cases in the Central Highlands region, Vietnam for a period of 2010- 2015. Methods: Serum samples from clinically suspected cases of dengue virus infection were collected. All samples were tested for Dengue IgM by indirect ELISA and by RT-PCR for presence of Dengue virus RNA. Results: A total of 3272 serum samples were tested, of which 1229 (37.5%) were positive for dengue. The Dengue positive patients were 565 males and 664 females. All four serotypes of Dengue virus have found in the Central Highlands region. DENV-2 was predominant in 2010, 2012 and 2013. DENV-3 and DENV-4 was predominant in 2014 and 2015; respectively. The Dengue affected cases were more in 20-40 years age group. Dengue cases were more during May to September in rainy season when weather conditions were prefer for mosquito bleeding and vector activity. Conclusions: The findings of this study indicate that all four serotypes of dengue virus are circulating in the Central Highlands region, Vietnam. The data enable to notice seasonal distribution of Dengue fever in the Central Highlands region, Vietnam over five years (2010-2015) with regards to outbreaks and peak incidences in the disease.