Science and Education Publishing American Journal of Epidemiology and Infectious Disease 2333-1275 3 4 2015 11 12 Levofloxacin - Induced Cutaneous Leukocytoclastic Vasculitis: Report of a Case in a Diabetic Man and Review of the Litterature 84 87 EN Sahar El Aoud Nadia Charfi Nessrine Cheikhrouhou Mariam Kesentini Mouna Elleuch Department of Endocrinology, Hedi Chaker Hospital, Sfax, Tunisia Tahia Boudawara Mohamed Abid AJEID2015343 10.12691/ajeid-3-4-3 2015 6 3 2015 9 21 2015 11 10 Cutaneous leukocytoclastic vasculitis comprises a wide spectrum of etiologies including medications. Fluoroquinolones are rarely implicated in this disease. We report the case of a diabetic man who was referred to our hospital for purpuric rash and hyperglycemia. The cutaneous lesions appeared 3 days after the begining of levofloxacin which was prescribed for a respiratory infection. Physical examination and laboratory evaluation findings ruled out renal, neurological, respiratory and gastrointestinal involvement. Skin biopsy confirmed the diagnosis of cutaneous leukocytoclastic vasculitis. Autoimmune investigations and infectious serologies were negative. Levofloxacin therapy was the most probable etiology. The patient was successfully treated by withdrawal of the offending antibiotic associated with topical steroids.