@article{ajeid2015331,
author={{Ledika, Masayu Amanda and Setiabudi, Djatnika and Dhamayanti, Meita},
title={Association between Clinical Profiles and Severe Dengue Infection in Children in Developing Country},
journal={American Journal of Epidemiology and Infectious Disease},
volume={3},
number={3},
pages={45--49},
year={2015},
url={http://pubs.sciepub.com/ajeid/3/3/1},
issn={2333-1275},
abstract={<b>Background</b>: Dengue virus infection is endemic and is one of major causes of morbidity and mortality in children. The cause of mortality in children with dengue infection was not limited to shock but also caused by severe bleeding and organ dysfunction. This study aim to to examined clinical profiles of children with dengue infection and their association with severe dengue. <b>Methodology and principal findings</b>: Cross每sectional study of children with dengue virus infection admitted to Department of Child Health, Hasan Sadikin Hospital Bandung from April 2013 to September 2014. Subjects were patient age 1每&lt;14 who fulfilled 2009 WHO criteria for dengue virus infection. Association between clinical profile and severe dengue infection was analyzed in two steps. After bivariate analysis, variable with p value &lt;0.25 was included in the next step by logistic regression. P value &lt;0.05 was consider significant. Of 451 subjects, 24.6% (n=111) had severe dengue infection. Dengue shock syndrome with or without other form of severe dengue was the most common complication and occured in 65.7% (n=73) of all severe dengue cases. Patient admitted ≡4th day of illness (OR 13.25 95%CI 3.45每50.86), persistent vomiting (OR 20.32 95%CI 7.41每55.74); hepatomegaly (OR 21.72 95%CI 7.73每61.01), platelet count &lt;50.000/mm<SUP>3</SUP> (OR 26.54 95%CI 8.59每81.99), and leukocyte ≡5000/mm<SUP>3</SUP> at admission (OR 4.25 95%CI 1.55每11.65) were associated with severe dengue infection. <b>Conclusion:</b> Clinical manifestation of severe dengue infection was not limited to dengue shock syndrome. Patient admitted ≡4th day of illness, persistent vomiting, hepatomegaly, platelet count &lt;50.000/mm<SUP>3</SUP> and leukocyte ≡5000/mm<SUP>3</SUP> at admission were associated with severe dengue infection in children.},
doi={10.12691/ajeid-3-3-1}
publisher={Science and Education Publishing}
}