eng Science and Education Publishing American Journal of Epidemiology and Infectious Disease 2333-1275 2022-06-30 10 2 40 49 10.12691/ajeid-10-2-1 AJEID20221021 article Fri A. Fonchin alycefri@gmail.com 1 2 Linda Basikolo 2 2 3 Simegnew A. Kallu 3 3 4 Henson Kainga 4 4 5 Jezreel Mwiinde 5 5 Vistorina Benhard 5 5 6 University of Zambia, Lusaka 10101, Zambia Background: The Corona Virus Disease of 2019 (COVID-19) was declared a disease of public health concern by the WHO in January 2020, one month after its emergent. Efforts have been made to raise and improve public awareness of COVID-19. Zambia has reported repeated waves of the COVID-19 pandemic with highest transmissions in Lusaka, the Copperbelt, and Ndola districts. PopulationsĄŻ knowledge, attitude, and perceptions (KAPs) towards COVID-19 have impacts on control and prevention measures. Despite the collection of research on KAPs towards COVID-19, the KAP of socio-ecological and socio-anthropological determinants regarding the disease remains speculative. Hence, this study investigates KAPs of socio-ecological and socio-anthropological determinants of COVID-19 among the inhabitants of Lusaka district of Zambia. Methodology: A total of 301 inhabitants from four Lusaka District Compounds were sampled by a simple random method using a cross-sectional study design and interview-based questionnaires data collection method to investigate the KAPs of ecological and anthropological determinants of COVID-19. The analysis included descriptive statistics, chi-square analysis for associations between participants KAPs towards COVID-19, and finally, a multivariate logistic regression to determine KAP predictors. Findings/conclusion: Majority of study participants were females (54.5%). 53.2% of the respondents were in the age group of 18¨C28 years, and mostly (53.5%) single. 46.5% participants had tertiary level of education and (57.8%) had a monthly income of 0-K1000. The overall KAP knowledge was moderate (67.1%), and only 51.5% of participants demonstrated a positive attitude towards preventing COVID-19 infections. Socio-demographic factors had a weak bearing on KAP and attitude scores, with levels of education and gender being the only significant variables, respectively. This study indicates a poor understanding of COVID-19 with respect to ecological and anthropological determinants. Governments need to ensure more awareness campaigns to improve the populationsĄŻ KAPs towards future infectious diseases that may occur. http://pubs.sciepub.com/ajeid/10/2/1/ajeid-10-2-1.pdf anthropological COVID-19 ecological Lusaka