@article{ajeid2013146,
author={{Asaad, Ahmed Morad and Qureshi, Mohamed Ansar},
title={Increased Vancomycin Minimum Inhibitory Concentrations of Methicillin-Resistant <i>Staphylococcus aureus</i> Nosocomial Isolates in Southwestern Saudi Arabia},
journal={American Journal of Epidemiology and Infectious Disease},
volume={1},
number={4},
pages={59--62},
year={2013},
url={http://pubs.sciepub.com/ajeid/1/4/6},
abstract={<b> </b> This study aimed to determine the distribution of vancomycin (VAN) MIC values and antimicrobial resistance patterns of MRSA nosocomial isolates from a Saudi tertiary care hospital and evaluate the presenting clinical and demographic features of different infections caused by these isolates. A total of 104 non-duplicating MRSA nosocomial strains were isolated. VAN MICs were determined by standard Etest and the Etest macromethod (MET). Among all isolates, 7.7% had a MIC = 2 ¦Ìg/ml, 70.2% had a MIC = 1 ¦Ìg/ml and 22.1% had a MIC = 0.5 ¦Ìg/ml. No heterogeneous VAN-intermediate<i> S. aureus</i> (hVISA) were detected. Patients infected with high VAN MRSA nosocomial isolates were of significantly older age (<i>p</i> = 0.035), presented more often with bacteraemia (<i>p </i>= &lt; 0.0001) and had longer hospital stays (<i>p </i>= &lt; 0.0001). The presence of high VAN MICs of some MRSA isolates in our hospital is worrying and a cause for concern due to the possibility of the potential failure of treatment of these isolates. Moreover, accurate MIC testing using MET simultaneously or as a supplement to automated systems (i.e. Vitek) is important.},
doi={10.12691/ajeid-1-4-6}
publisher={Science and Education Publishing}
}