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Science and Education Publishing (SciEP) is a multidisciplinary open access publisher of Journals covering the fields of Science, Technology and Medicine. All SciEP publications are subject to high-quality peer review, editorial and production processes and are freely available online.

Welcome to the April, 2013 edition of SciEP newsletter, providing monthly summaries of articles on science & education related topics of interest to scientist and professionals. The mission of our journals is to provide an open access forum for publishing new findings on issues pertinent to scientific and academic field. We also invite you to submit original research papers, review articles, short reports, or case studies are considered for publication in our Multidisciplinary Journals.

American Journal of Public Health Research
DOI: 10.12691/ajphr-1-1-3

The Implementation of a Tele-Homecare System with Service Oriented Architecture and HL7 Message Transmission Standard
Ching-Sung Wang

American Journal of Medical and Biological Research
DOI: 10.12691/ajmbr-1-1-2

The Influence of Ethanol on Pyruvate Kinases Activity in Vivo, in Vitro, in Silico
Lelevich Sergey Vladimirovich, Khrustalev Vladislav Victorovich, Barkovsky Eugene Victorovich, Shedogubova Tatyana Aleksandrovna

American Journal of Medical Sciences and Medicine
DOI: 10.12691/ajmsm-1-1-1

Clinical and Histological Features in Wegener Granulomatosis
Li Cavoli Gioacchino, Passantino Rita, Bono Luisa, Tortorici Calogera, Ferrantelli Angelo, Giammarresi Carlo, Rotolo Ugo

American Journal of Infectious Diseases and Microbiology
DOI: 10.12691/ajidm-1-1-2

The Curse of Lymphatic Filariasis: Would the Continual Use of Diethylcarbamazine Eliminate this Scourge in Papua New Guinea?
Anne Lanham, Lillian Mwanri

We have released issues of some journals on February 2013.
American Journal of Public Health Research
American Journal of Medical Sciences and Medicine
American Journal of Medical and Biological Research
American Journal of Pharmacological Sciences
American Journal of Clinical Medicine Research
American Journal of Nursing Research
American Journal of Cancer Prevention
American Journal of Medicine Studies
American Journal of Infectious Diseases and Microbiology
American Journal of Cardiovascular Disease Research
American Journal of Biomedical Research
American Journal of Mechanical Engineering
American Journal of Microbiological Research
Journal of Preventive Medicine
American Journal of Food and Nutrition
American Journal of Hypertension Research
American Journal of Sports Science and Medicine
Journal of Cancer Research and Treatment
American Journal of Zoological Research
Journal of Biomedical Engineering and Technology
American Journal of Microbiological Research
Biomedical Science and Engineering

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Brentuximab for Refactory Hodgkin’s Lymphoma: A Case Report

Edris Sadeghi, Mehrdad Payandeh*

Department of Hematology and Medical Oncology, Kermanshah University of Medical Sciences, Kermanshah, Iran

Abstract: Hodgkin's lymphoma (HL) continues to be an intriguing, and fascinating lymphoma [1]. HL is expected to cure the majority of patients. Brentuximab vedotin is a CD30 antibody. We survey efficacy of brentuximab in patient with HL who was resistant to treatment. A 43 year old male referred with cough and right supraclavicular lymphadenopathy. His disease was HL, nodular sclerosis type (stage IIB and grade II) with megakaryocytosis in bone marrow aspiration (BMB). He was treated with 6 cycles of induction chemotherapy including adriamycin, bleomycin, vinblastine and dacarbazine (ABVD) and achieved a complete remission by imaging assessment. Then he received ifosfamide, carboplatin, etoposide (ICE) plus brentuximab vedotin (1.8 mg/kg every 3 weeks) regimen for 6 courses. At the end of this time he been eligible for autologous bone marrow transplantation (BMT). Bone marrow was done and after 13 days with good engraftment the patient discharge hospital. Therapists should be try with a specific target when they need a new and potent treatment like BMT for an active disease. Brentuximab vendotin is a new drug in policy of recurrence that it used for a few of cases in Iran.

Keywords: ABVD, BMT, brentuximab, Hodgkin's Lymphoma

Citation: Edris Sadeghi, Mehrdad Payandeh, Brentuximab for Refactory Hodgkin’s Lymphoma: A Case Report. American Journal of Cancer Prevention, 5 (3). 39-40. January 2017. doi:10.12691/ajcp-5-3-4

1. Introduction

Originally described by Thomas Hodgkin in 1832, and described as “morbid experiences of the absorbent glands and spleen”, Hodgkin's lymphoma (HL) continues to be an intriguing, and fascinating lymphoma [1]. HL is expected to cure the majority of patients. Patients with advanced stage disease have 5-year overall survival more than 80% [2]. Treatment of relapsed and primary refractory patients still remains a challenge. Median survival of patients relapsing after second-line, high-dose therapy and autologous stem cell transplantation is less than 3 years [3]. However, the antibody-drug conjugate brentuximab vedotin has shown promising efficacy in these patients [4]. We survey efficacy of brentuximab in patient with HL who was resistant to treatment.

2. Case Presentation

A 43 year old male referred with cough and right supraclavicular lymphadenopathy. His disease was HL, nodular sclerosis type (stage IIB and grade II) with megakaryocytosis in bone marrow aspiration (BMB). He was treated with 6 cycles of induction chemotherapy including adriamycin, bleomycin, vinblastine and dacarbazine (ABVD) and achieved a complete remission by imaging assessment. Positron emission tomography (PET) scan showed hyper metabolic anterior mediastina right parasternal mass with anterior chest and parahilar extension and adjacent pericardial and pleural thickening (hyper metabolic small mediastinal lymph node). Hyper metabolic focus in intercostal space). He underwent 36 Gy/18F radiation therapy for 21 sessions involved fields. He followed up for about 12 months. After that he suffered from lung and pericardial perfusion that in PET scan analysis confirmed active disease that in lung lesion core biopsy established with recurrent disease. Then he received ifosfamide, carboplatin, etoposide (ICE) plus brentuximab vedotin (1.8 mg/kg every 3 weeks) regimen for 6 courses. At the end of this time he been eligible for autologous bone marrow transplantation (BMT). Bone marrow was done and after 13 days with good engraftment the patient discharge hospital.

3. Discussion

HL is a highly curable hematologic malignancy treated with the combination chemotherapy with or without RT. ABVD is the preferred first-line combination chemotherapy for HL. Following treatment with 6–8 cycles of ABVD, >70% of patients are considered to be cured. However, conventional dose chemotherapy is not sufficient to cure refractory or early relapsing cases [5] like this study and also the patient received ICE. Brentuximab vedotin is a CD30 antibody conjugated to CD30 and gets internalized by attaching to monomethyl auristatin E causing microtubule disruption that results in cell cycle arrest at M phase [6]. BMT use for patient with early relapse young case of HL but it is critical in the compilation of treatment versa we used Brentuximab vedotin there. Adverse effects including peripheral neuropathy, elevated aminotransferases, hair loss, and dry cough appeared but could be controlled with symptomatic treatments. Serious adverse effects, such as lung damage and leukoencephalopathy [4].

4. Conclusion

Therapists should be try with a specific target when they need a new and potent treatment like BMT for an active disease. Brentuximab vendotin is a new drug in policy of recurrence that it used for a few of cases in Iran.

References

[1]   | Classics in oncology. Excerpts from: On some morbid appearances of the absorbent glands and spleen, Thomas Hodgkin. CA Cancer J Clin. 1973; 23(1):54-60.
[2]   | Skoetz N, Trelle S, Rancea M, Haverkamp H, Diehl V, Engert A, Borchmann P. Effect of initial treatment strategy on survival of patients with advanced-stage Hodgkin's lymphoma: a systematic review and network meta-analysis. The Lancet Oncology. 2013; 14(10): 943-952.
[3]   | S Horning MF, S DeVos, P Borchmann, T Illidge, A Engert, S Arai AY, S Horning, M Fanale. Defining a population of Hodgkin lymphoma patients for novel therapeutics: an international effort. Annals of Oncology. 2008; 20, article 118.
[4]   | Younes A, Bartlett NL, Leonard JP, Kennedy DA, Lynch CM, Sievers EL, Forero-Torres A. Brentuximab vedotin (SGN-35) for relapsed CD30-positive lymphomas. N Engl J Med. 2010; 363(19): 1812-21.
[5]   | Peipei Xu, Fan Wang, Chaoyang Guan, Jian Ouyang, Xiaoyan Shao, and Bing Chen. A case report and literature review of primary resistant Hodgkin lymphoma: a response to anti-PD-1 after failure of autologous stem cell transplantation and brentuximab vedotin. Onco Targets Ther. 2016; 9: 5781-5789.
[6]   | Dumaswala K, Mehta A. Novel agents for the treatment of Hodgkin lymphoma. Exp Rev Hematol. 2015; 8(5): 659-667.