eng Science and Education Publishing American Journal of Cancer Prevention 2328-7314 2017-10-10 5 3 35 36 10.12691/ajcp-5-3-2 AJCP2017532 article Mehrdad Payandeh 1 Noorodin Karami 2 Afshin Karami afshinkarami72@gmail.com 3 Department of Hematology and Medical Oncology, Kermanshah University of Medical Sciences, Kermanshah, Iran Department of Genetic, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Department of Hematology, Shahid Beheshti University of Medical Sciences, Tehran, Iran First, the term Cutaneous T-cell lymphoma (CTCL) was used by Edelson to describe Mycosis Fungoides (MF) and Sézary Syndrome (SS), which are lymphoproliferative disorders. The most frequent subtype is MF that the exact etiology of the disease is unclear and there is a therapeutic challenge in treating these patients. In this study, we report the patients who initially were treated with combination chemotherapy regimens, but after a while, due to their resistance to these drugs, their treatment was changed and now, their condition is relatively favorable. Therefore, we suggest that further investigations on the prognostic factors associated with this disease are needed that are crucial in terms of response to therapy in these patients. http://pubs.sciepub.com/ajcp/5/3/2/ajcp-5-3-2.pdf Cutaneous T-cell lymphoma CTCL Mycosis Fungoides