eng Science and Education Publishing American Journal of Cancer Prevention 2328-7314 2016-08-06 4 3 36 40 10.12691/ajcp-4-3-1 AJCP2016431 article Nassar Ayoub Abdellatif Omar 1 2 Amal Nor Edeen Ahmad Allithy 3 4 Hussam Baghdadi 5 Mohammed Zolaly 6 Mohamed Abdel-haleem 7 Manal Mohamed Helmy 8 9 Mongi Mohamed Ahmed Ayat 9 10 Salah Mohamed El Sayed salahfazara@yahoo.com 10 11 Department of Anatomy, Faculty of Clinical Pharmacy, Taif University, KSA Department of Pathology, Al-Ghad International Medical Sciences Colleges, Al-Madinah, KSA Department of Clinical Biochemistry and Molecular Medicine, Taibah Faculty of Medicine, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia Department of Pediatrics, College of Medicine, Taibah College of Medicine, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia Department of ear, nose and throat surgery, Taibah Faculty of Medicine, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia Department of Pediatrics, Sohag Teaching Hospital, Sohag, Egypt Doxorubicin (DOX) is a currently used broad spectrum anticancer agent used to treat many cancer types. DOX belongs to anthracycline group of cytotoxic drugs. Unfortunately, DOX induces many side effects e.g. cardiotoxicity, hepatotoxicity and nephrotoxicity. In this experimental study, we assessed the protective potential of honey bee propolis against DOX-induced side effects. Thirty Sprague Dawley male rats (weighing about 200-220 g) were included in our study and divided into three equal experimental groups: group I (untreated control), group II (DOX-treated rats) that received 25 mg/kg DOX by intraperitoneal (i.p) injection for three consecutive days and group III where animals received both DOX and propolis oral propolis (250 mg/kg for 30 consecutive days). By the end of experimental time, all animals were sacrificed on the 30th day where blood samples and tissue sections were collected for detection of the biochemical and histopathological changes. Our data revealed that propolis evidently resulted in hepatoprotective effects against DOX-induced toxicity in rats liver. It can be concluded that propolis provides partial protection against DOX-induced hepatotoxicity. http://pubs.sciepub.com/ajcp/4/3/1/ajcp-4-3-1.pdf Doxorubicin Liver toxicity anthracyclines Bee propolis Chemotherapy