Science and Education Publishing American Journal of Cancer Prevention 2328-7314 4 1 2016 4 26 The Effect of Local Regional Therapy on Post-transplantation Survival Rate in Patients with Hepatocellular Carcinoma 18 22 EN Wei Chen Xiaoli Yang Yakun Wu Department of Hepatobiliary Surgery, Suining Central Hospital, Suining 629000, China AJCP2016414 10.12691/ajcp-4-1-4 2015 11 22 2016 4 4 2016 4 24 Background and Objective: This study aims to use meta-analysis to evaluate whether pre-transplantation local regional therapy (LRT) can improve the survival of patients with hepatocellular carcinoma who accepted liver transplantation. Methods: Relevant studies were identified by searching PUBMED, EMBASE and Web of Science Datebases up to May 2015. Endpoints were 1 year, 3 years, and 5 years survival rate after liver transplantation. Results: Analysis of nine retrospective studies including 1097 patients did not reveal significant difference in 1year, 3 years and 5 years survival rate between the patients who got LRT or not. Analysis of four retrospective studies including 504 patients showed patients with complete response to LRT have higher 5 years survival rate. Conclusions: The results of this meta-analysis suggest that the patients with complete response to LRT have higher post-transplantation survival rate. But LRT before liver transplantation can't improve the overall survival rate.