eng Science and Education Publishing American Journal of Cancer Prevention 2328-7314 2016-04-26 4 1 18 22 10.12691/ajcp-4-1-4 AJCP2016414 article Wei Chen 1 Xiaoli Yang 2 Yakun Wu 353827514@qq.coml 3 Department of General Surgery, Hospital of traditional Chinese medicine of Yubei, Chongqing, 400010, China Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China Department of Hepatobiliary Surgery, Suining Central Hospital, Suining 629000, China Background and Objective: This study aims to use meta-analysis to evaluate whether pre-transplantation local regional therapy (LRT) can improve the survival of patients with hepatocellular carcinoma who accepted liver transplantation. Methods: Relevant studies were identified by searching PUBMED, EMBASE and Web of Science Datebases up to May 2015. Endpoints were 1 year, 3 years, and 5 years survival rate after liver transplantation. Results: Analysis of nine retrospective studies including 1097 patients did not reveal significant difference in 1year, 3 years and 5 years survival rate between the patients who got LRT or not. Analysis of four retrospective studies including 504 patients showed patients with complete response to LRT have higher 5 years survival rate. Conclusions: The results of this meta-analysis suggest that the patients with complete response to LRT have higher post-transplantation survival rate. But LRT before liver transplantation can't improve the overall survival rate. http://pubs.sciepub.com/ajcp/4/1/4/ajcp-4-1-4.pdf liver transplantation hepatocellular carcinoma local regional therapy meta-analysis