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Welcome to the April, 2013 edition of SciEP newsletter, providing monthly summaries of articles on science & education related topics of interest to scientist and professionals. The mission of our journals is to provide an open access forum for publishing new findings on issues pertinent to scientific and academic field. We also invite you to submit original research papers, review articles, short reports, or case studies are considered for publication in our Multidisciplinary Journals.

American Journal of Public Health Research
DOI: 10.12691/ajphr-1-1-3

The Implementation of a Tele-Homecare System with Service Oriented Architecture and HL7 Message Transmission Standard
Ching-Sung Wang

American Journal of Medical and Biological Research
DOI: 10.12691/ajmbr-1-1-2

The Influence of Ethanol on Pyruvate Kinases Activity in Vivo, in Vitro, in Silico
Lelevich Sergey Vladimirovich, Khrustalev Vladislav Victorovich, Barkovsky Eugene Victorovich, Shedogubova Tatyana Aleksandrovna

American Journal of Medical Sciences and Medicine
DOI: 10.12691/ajmsm-1-1-1

Clinical and Histological Features in Wegener Granulomatosis
Li Cavoli Gioacchino, Passantino Rita, Bono Luisa, Tortorici Calogera, Ferrantelli Angelo, Giammarresi Carlo, Rotolo Ugo

American Journal of Infectious Diseases and Microbiology
DOI: 10.12691/ajidm-1-1-2

The Curse of Lymphatic Filariasis: Would the Continual Use of Diethylcarbamazine Eliminate this Scourge in Papua New Guinea?
Anne Lanham, Lillian Mwanri

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American Journal of Medical and Biological Research
American Journal of Pharmacological Sciences
American Journal of Clinical Medicine Research
American Journal of Nursing Research
American Journal of Cancer Prevention
American Journal of Medicine Studies
American Journal of Infectious Diseases and Microbiology
American Journal of Cardiovascular Disease Research
American Journal of Biomedical Research
American Journal of Mechanical Engineering
American Journal of Microbiological Research
Journal of Preventive Medicine
American Journal of Food and Nutrition
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Journal of Cancer Research and Treatment
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Rectal Adenocarcinoma after Diffuse Large B-cell Lymphoma of the Ileocecal: Case Report

Mehrdad Payandeh, Edris Sadeghi*, Masoud Sadeghi, Mostafa Hossini

Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran

Abstract: Introduction: The incidence of primary colorectal lymphomas is rare, comprising 10-20% of gastrointestinal lymphomas and only 0.2-0.6% of large bowel malignancies. The aim of this study is report a rare case with rectal adenocarcinoma in patient with diffuse large B-cell lymphoma of the ileocecal. Case Report: A 33-year-old female presented to the Talaghani hospital in September 2003 with serious condition and with acute abdominal symptoms, so she underwent treatment and surgery. Some lymph nodes near the tumor were great. In pathological microscopic revealed a white fungative mass measuring 3*3 cm, in cecal luman at the ileocecal junction. She was treated with six cycles of chop (cyclophosphamide + doxorubicin + vincristine + prednisolone) chemotherapy. She responded to this treatment good for kind of indolent non-Hodgkin's lymphoma because she had stable statues for about 11 years. So we understood the patient had high cancer antigen level from laboratory test and rectal biopsy showed moderately differentiated adenocarcinoms. Conclusion: We recommend screen colonoscopy in this case for as soon as diagnosis for colon cancer in after bowel irradiation and also it is probability long close follow up and irradiation therapy in lymphoma phase create new adenocarcinoma of colon.

Keywords: Diffuse Large B-cell Lymphoma, Ileocecal, Rectal Adenocarcinoma

Received May 20, 2015; Revised September 10, 2015; Accepted October 07, 2015

Citation: Mehrdad Payandeh, Edris Sadeghi, Masoud Sadeghi, Mostafa Hossini, Rectal Adenocarcinoma after Diffuse Large B-cell Lymphoma of the Ileocecal: Case Report. American Journal of Cancer Prevention, 3 (5). 94-95. January 2015. doi:10.12691/ajcp-3-5-5

1. Introduction

The incidence of primary colorectal lymphomas is rare, comprising 10-20% of gastrointestinal lymphomas and only 0.2-0.6% of large bowel malignancies. Of these large bowel lymphomas, 60% are located in the caecum, 20% in the rectum, and the remainder throughout the colon [1]. On histological examination, almost 90% of the primary GI lymphomas are of B-cell lineage with very few T-cell lymphomas and Hodgkin lymphoma [2]. Very little is known about the correlation between adenoma and lymphoma in the colorectal tract [3]. The aim of this study is report a rare case with rectal adenocarcinoma in patient with diffuse large B-cell lymphoma of the ileocecal.

2. Case Report

A 33-year-old female presented to the Talaghani hospital in September 2003 with serious condition and with acute abdominal symptoms, so she underwent treatment and surgery. In laparotomies cecum and appendix of the patient, the tumor was attached to the posterior and external wall. The tumor was removed and right hemicolectomy was done. The liver metastatic lesion was not found. But some lymph nodes near the tumor were great. In pathological microscopic revealed a white fungative mass measuring 3*3 cm, in cecal luman at the ileocecal junction. Appendix was not identified and macroscopic reported ileocecal tumor compatible with malignant lymphoma (diffuse large B cell) (Figure 1). She was treated with six cycles of chop (cyclophosphamide + doxorubicin + vincristine + prednisolone ) chemotherapy. She responded to this treatment good for kind of indolent non-Hodgkin's lymphoma because she had stable statues for about 11 years. Therefore we follow up and check up her in this period of the time and she did not any serious problem. Unfortunately, she had complaint of her abdominal again. So we understood the patient had high cancer antigen level from laboratory test and rectal biopsy showed moderately differentiated adenocarcinoms. Then she got six cycles of oxaliplatin and capecitabine (Xeloda ®) and two month radiotherapy. She referred for R/O KRAS and NRAS mutations that she had KRAS mutant with carriers mutation on p.Gly12Asp(c.35G>A) and wild type NRAS. So bevacizumab added to this policy of chemotherapy. The patient is alive continue to these policy of treatment.

Figure 1. medium-to-large-sized lymphocytes with scanty cytoplasm

3. Discussion

The ileocecal area and ileum are the regions most frequently affected by primary small-intestinal and largeintestinal NHL. Colorectal lymphoma is extremely infrequent, representing less than 0.5% of all primary colorectal neoplasms [4]. Many factors and mechanisms may play a role in the occurrence of synchronous colonic carcinoma and lymphoma [5]. Among these are included environmental agents, immune abnormalities and genetic constitution of the patients [6]. Moriya et al. [7] reported a case in which diagnosis of synchronous malignant lymphoma was made on 2nd surgery, a month after patient was diagnosed with colonic adenocarcinoma after right hemicolectomy. Another case of adenocarcinoma cecum with simultaneous follicular lymphoma of the terminal ileum and regional nodes was reported by Bhanote et al [8].

4. Conclusion

We recommend screen colonoscopy in this case for as soon as diagnosis for colon cancer in after bowel irradiation and also it is probability long close follow up and irradiation therapy in lymphoma phase create new adenocarcinoma of colon.

References

[1]   | Wong MT, Eu KW. Primary colorectal lymphomas. Colorectal Dis. 2006. 8 (7): 586-91.
[2]   | Genovese F, Becchina G, Nagar C, Ottoveggio G, Giacalone B, Scaglione G, Varriale E, Tralongo V. Primary diffuse large B-cell lymphoma developing within a rectal tubular adenoma with low-gradedysplasia: a case report. J Med Case Rep. 2014. 8: 103.
[3]   | Sato H, Yasumi K, Mizuno Y, Ichikawa T, Honda K, Kuroda M. Primary T-cell lymphoma associated with tubulovillous adenoma of the rectum: report of a case. Surg Today. 2013. 43 (3): 317-20.
[4]   | Roeb E, Rummel M, Blau W, Etschmann B, Gattenlöhner S. B-cell lymphoma in a tubular adenoma with high-grade dysplasia: a rare extramedullary manifestation of high-grade diffuse large B-cell lymphoma. Endoscopy. 2011.43 Suppl 2 UCTN: E344-5.
[5]   | Nishimura Y, Takenaka H, Yoshidome K, Iwase K, Oshima S, Tanaka T. Primary mesenteric tumor of adult T-cell leukemia/lymphoma: report of a case. Surg Today. 1994, 24 (3): 263-67.
[6]   | Quilon JM, Day S, Lasker JC. Synchronous tumors: Hodgkin disease presenting in mesenteric lymph nodes from a right hemicolectomy for colon carcinoma.South Med J. 2004. 97: 1133-35.
[7]   | Moriya Y, Koyama Y, Minato K, Shimoyama M, Hirota T, Itabashi M. Coexisting malignant lymphoma and advanced adenocarcinoma of the colon: A case report. Gan No Rinsho. 1985; 31: 894-9.
[8]   | Bhanote M, Choksi M, Cassar P, Edelman M, DellaRatta R, Staszewski H. Metastatic adenocarcinoma of the colon and follicular lymphoma within the same lymph node: A case report and review of literature. Int J Gastrointest Cancer. 2005; 36 (3): 171-5.