eng Science and Education Publishing American Journal of Cancer Prevention 2328-7314 2023-06-09 10 1 12 13 10.12691/ajcp-10-1-3 AJCP20231013 article Ehteshamul Hoque ehtesham@dhaka.net 1 Safayet Hossain 2 Senior Consultant, Department of Radiotherapy, Labaid Cancer Hospital & Amp, Super Specialty Center, Dhaka, Bangladesh Manager, Oncology, Beacon Pharmaceuticals Limited, Dhaka, Bangladesh Introduction: The recurrence of any type of cancer can be a great physical, mental and financial burden for the patients, and can also negatively impact the overall health status of a country. Despite the availability of multiple treatment methods, patients with recurrence of cancer still show up. Which is why, the present study of 2 recurrent carcinoma patients, who after being treated with immunotherapy, did no see any recurrence and observed significant clinical and radiological improvement, is of great importance. Case Presentation: This study was conducted with 2 cases of recurrent head and neck cancer, both of whom were Bangladeshi female. The first patient was 70-year-old, while the second patient was 59 years old. Both had received multiple previous treatment, including surgical treatment and chemotherapy, but still had recurrence of cancer. Conclusion: The use of immunotherapy in recurring Head & Neck Cancer shows promising Clinical and Radiological response, with much fewer observable side-effects compared to previous treatment methods. http://pubs.sciepub.com/ajcp/10/1/3/ajcp-10-1-3.pdf cancer carcinoma immunotherapy chemotherapy chemoradiotherapy