eng Science and Education Publishing American Journal of Clinical Medicine Research 2328-403X 2020-12-29 9 1 10 13 10.12691/ajcmr-9-1-3 AJCMR2021913 article Lujiang Yi 1 Ye Jiang 1 Lu Yang nollen@163.com 2 #These authors contributed equally to this work. Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, P. R. China Hericium erinaceus polysaccharide (HEP) is a Chinese herb and was reported to regulate the immune response effectively in different aspects. This study was aimed to investigate the influence of HEP on murine dendritic cells (DC). In this study, we found that HEP treatment induced DC maturation by the morphology and the up-regulation of co-stimulative molecules. The endocytosis activity was also reduced, which is also an important feature of maturation. HEP also increased the allogenic T cell proliferation in a MLR assay. Furthermore, it was found that HEP increase the expression level of IL-12. Finally, we concluded that HEP induced maturation of bone marrow DC. http://pubs.sciepub.com/ajcmr/9/1/3/ajcmr-9-1-3.pdf Hericium erinaceus polysaccharide Chinese herb immunity Dendritic cells