eng Science and Education Publishing American Journal of Clinical Medicine Research 2328-403X 2019-10-30 7 2 57 59 10.12691/ajcmr-7-2-5 AJCMR2019725 article Kunio Yui yui16@bell.ocn.ne.jp 1 George Imataka 2 Hitomi Sasaki 2 Ryoichi Shiroki 2 Department of Urology, Fujita Health University School of Medicine, Aichi, Toyoake, 470-1192, Japan Department of Pediatrics, Dokkyo Medical University, Mibu 321-0293, Tochigi,Mibu, Japan This case study examined the association between epileptic activity such as epileptiform discharges and autistic symptoms; and to examine the effect of mTOR inhibitor everolimus on seizures and epileptiform discharges in three cases with TSC and autistic symptoms. The everolimus treatment improved autistic symptoms in all four cases, however, epileptiform discharges did not disappear in all four cases with everolimus treatment. Thus, epileptiform activity and autistic symptoms may be two end-results of separate brain dysfunction. The evrolimus treatment disappeared a seizure in only one case, suggesting partial overlap between mTOR hyperactivity and a seizure in small subset of cases with TSC. This study for firstly revealed that the everolimus treatment was inefficient for epileptiform discharges. Antiepileptic therapy at early stage of brain development might be effective for epileptic activity. http://pubs.sciepub.com/ajcmr/7/2/5/ajcmr-7-2-5.pdf tuberous sclerosis complex seizure control Epileptiform discharges autistic symptoms mTOR inhibitor