eng Science and Education Publishing American Journal of Clinical Medicine Research 2328-403X 2017-07-11 5 4 49 51 10.12691/ajcmr-5-4-2 AJCMR2017542 article Mohammedelhassan Ahmed Mohammedelhassan malomalomalo@live.ru 1 Mamoun Magzoub 2 Neurologist, Medical Military Hospital, Omdurman, Sudan Faculty of Medical Laboratory Sciences, International University of Africa, Khartoum, Sudan Objective: Migraine is one of the most frequent disabling neurological conditions and very bad headache with a major impact on the patient's quality of life. The objective of this study was to evaluate the effectiveness of Prednisolone in treating migraine. Methods: A cross sectional, hospital-based study was conducted. All patients (1020) were received Prednisolone 0.5 mg/kg/day for 7 days followed by tapering by 1 tablet (5 mg) every 7 days. The patients were followed minimally for six months after receiving treatment. Results: All patients responded to the treatment and all their associated symptoms disappeared. We think this approach is the best one for treating migraine. Conclusion: We think that our approach is the best one in treating migraine, so our recommendation is to use steroids (Prednisolone tablets, in a dose of 0.5 mg / kg/day for 7 days, followed by tapering by 1 tablet (5 mg) every 7 days) as a protocol for the treatment of migraine. The individual dose adjustment is required in certain cases. From this study we conclude that, firstly we can say we have got the answer of the big question: what is migraine. Secondly, we think we present a nice explanation of the vascular phenomenon associated with migraine. Number third, we introduce new common symptom associated with migraine. Lastly we introduce new and effective treatment for migraine. http://pubs.sciepub.com/ajcmr/5/4/2/ajcmr-5-4-2.pdf migraine new treatment steroids