@article{ajcmr2017532,
author={{Fadlyana, Eddy and Ma¡¯ani, Fathiyah and Elizabeth, Monalisa and Reniarti, Lelani},
title={Correlation between Serum Ferritin Level and Growth Disorders in Children with Thalassemia},
journal={American Journal of Clinical Medicine Research},
volume={5},
number={3},
pages={31--35},
year={2017},
url={http://pubs.sciepub.com/ajcmr/5/3/2},
issn={2328-403X},
abstract={<i><b>Background </b></i>Children with thalassemia receiving regular blood transfusions without optimal iron chelation may experience high levels of iron. This condition can cause oxidative stress and affect the certain organs including endocrine organs leading to growth disorders.<b> </b><i><b>Objective</b></i> To determine the correlation between serum ferritin levels and growth disorders in children with thalassemia. <i><b>Methods</b></i><b> </b>This was a cross sectional study conducted during April-May 2015 at Children Thalassemia Clinic, Dr. Hasan General Sadikin Hospital, Bandung. The subjects were collected using consecutive sampling. The subjects were 93 children with thalassemia aged 10¨C14 years divided into several groups. The study used secondary data taken from the previous studies. The data were analyzed statistically using chi-square test to determine the correlation of both variables. The correlation between serum ferritin levels and growth disorders was examined by using point-biserial correlation and logistic regression models was used to determine the correlation between age and serum ferritin levels with short stature.<b> </b><i><b>Results</b></i> The study included 46 boys (49%) and 47 girls (51%), 62% of which had short statures. The results revealed that the mean serum ferritin level (SD) was 4.355,9 (2.149) ¦Ìg/L. The correlation between serum ferritin levels and growth disorders (r=-0.260;p=0.012) by ROC value was 3542 ¦Ìg/L. There was a significant correlation between age and serum ferritin levels with short stature (OR=3.248, CI95%1.304¨C8.086; OR=3.964, CI95%1.192¨C13.190). <i><b>Conclusion</b></i><b> </b>There was significant correlation<b> </b>between serum ferritin levels and growth disorders.},
doi={10.12691/ajcmr-5-3-2}
publisher={Science and Education Publishing}
}