Science and Education Publishing American Journal of Clinical Medicine Research 2328-403X 3 4 2015 10 21 Systemic Lupus Erythematosus (SLE): A 360 Degree Review 60 63 EN Alisa Nobee Angel Justiz Vaillant Department of Para-Clinical Sciences, Faculty of Medical Sciences, The University of the West Indies, Trinidad and Tobago, West Indies Patrick Eberechi Akpaka Peter Poon-king AJCMR2015341 10.12691/ajcmr-3-4-1 2015 6 7 2015 8 17 2015 10 19 In this paper we review the most important updated aspects of SLE, which is an autoimmune disorder of unknown etiology, where genetic, environmental and immunological factors are believed to play an important role in its immunopathogenesis. Aspects related to SLE causes, pathophysiology, signs and symptoms, diagnosis and treatment are discussed.