eng Science and Education Publishing American Journal of Clinical Medicine Research 2328-403X 2015-10-21 3 4 60 63 10.12691/ajcmr-3-4-1 AJCMR2015341 article Alisa Nobee 1 Angel Justiz Vaillant Angel.Vaillant@sta.uwi.edu 1 Patrick Eberechi Akpaka 1 Peter Poon-king 2 Department of Para-Clinical Sciences, Faculty of Medical Sciences, The University of the West Indies, Trinidad and Tobago, West Indies San Fernando General Hospital, San Fernando, Trinidad and Tobago, West Indies In this paper we review the most important updated aspects of SLE, which is an autoimmune disorder of unknown etiology, where genetic, environmental and immunological factors are believed to play an important role in its immunopathogenesis. Aspects related to SLE causes, pathophysiology, signs and symptoms, diagnosis and treatment are discussed. http://pubs.sciepub.com/ajcmr/3/4/1/ajcmr-3-4-1.pdf systemic lupus erythematosus autoimmune disease immunoglobulin immunology rheumatology