@article{ajcmr2015332,
author={{OA, Obisesan and TO, Ogundeko and CU, Iheanacho and T, Abdulrazak and VC, Idyu and II, Idyu and AH, Isa},
title={Evaluation of Alpha (¦Á) and Beta (¦Â) Haemolysin Antibodies Incidence among Blood Group ¡®O¡¯ Donors in ATBUTH Bauchi- Nigeria},
journal={American Journal of Clinical Medicine Research},
volume={3},
number={3},
pages={42--44},
year={2015},
url={http://pubs.sciepub.com/ajcmr/3/3/2},
issn={2328-403X},
abstract={<b>Background</b>: Antibodies with haemolytic properties are common within the ABO system. These lytic antibodies are immunoglobulin G (IgG) and in high titres cause haemolysis during blood transfusion. Information on Immunoglobulin types and concentration of ABO haemolysins in Nigerian population is not readily available especially in Northern Nigeria. <b>Methods:</b><b> </b>Serum samples from 200 males and 25 females O group blood donors were screened for A and B haemolysins. Forty two positive samples (38 males and 4 females) were treated with dithiothretiol (DTT) for characterization of IgG class. Antibody titre was compared with grade of haemolysis. <b>Results:</b> Out of 50 positive samples 42 highly haemolytic serum samples had IgG titres of > or = 64 after treatment with DTT. There was 18.6% occurrence of ¦Á and or ¦Â haemolysins in blood group O donors also with average titre values of ¦Á-haemolysins (68.2) and ¦Â-haemolysins (67).<b>Conclusion:</b> Results showsclear indication of high incidence of ¦Á and ¦Â haemolysins among the healthy blood group O donors hence, Haemolysin test was found to be a useful screening test to identify group O donors with high levels of IgG anti A and/or anti B as far as safe blood transfusion is concerned. <b>Aim:</b><b> </b>The study was determined the incidence of ? and ¦Â haemolysins in healthy blood group O donors in the Blood Bank Unit of ATBUTH Bauchi.},
doi={10.12691/ajcmr-3-3-2}
publisher={Science and Education Publishing}
}