eng Science and Education Publishing American Journal of Clinical Medicine Research 2328-403X 2014-12-22 2 6 111 113 10.12691/ajcmr-2-6-2 AJCMR2014262 article Sabitha kandi 1 B Venu Gopal 1 Raj Kumar G 1 MD Rafi 1 T Sudhakar 1 C Ramadevi 2 Mamatha 2 Pragna Rao 3 K V Ramana ramana_20021@rediffmail.com 4 Department of Biochemistry, Chalmeda Anandrao Institute of Medical Sciences, Karimnagar, India Department of Obstetrics and Gynaecology, Chalmeda Anandrao Institute of Medical Sciences, Karimnagar, India Department of Biochemistry, Kasturba Medical College, Manipal University, Manipal, India Department of Microbiology, Prathima Institute of Medical Sciences, Karimnagar, India Preeclampsia is a severe disorder of pregnancy characterized by the development of hypertension and proteinuria, increased vascular resistance and endothelial dysfunction in the mother, altered placental perfusion and restricted fetal growth. There is increased release of soluble growth factor like sFlt 1 from placenta, which decreases the availability of Vascular Endothelial Growth Factor(VEGF) receptors and decreases the availability of endothelial Nitric Oxide synthase. This inturn decreases the diastolic relaxation and endothelial dysfunction, podocyte injury of glomerular cells, increased excretion of podocyte specific proteins in urine leads to proteinuria. Cardiac hypertrophy further complicates the heart function. There is a raise in liver function; soluble factor like tyrosine kinase 1 (sFlt 1) may cause a disturbance in thyroid hormone function, thus prone to thyroid problem during or after pregnancy. http://pubs.sciepub.com/ajcmr/2/6/2/ajcmr-2-6-2.pdf preeclampsia proteinuria cardiac hypertrophy soluble factor like tyrosine kinase 1 (sFlt 1) endothelial dysfunction