@article{ajcmr2014219,
author={{Arbagy, Ahmed Rabie El and Koura, Mahmoud Abd El Aziz and Nasr, Abd El Samad Sobhy Abou El and Elbarbary, Hany Said},
title={Study of Effect of High-Flux Versus Low-Flux Dialysis Membranes on Parathyroid Hormone},
journal={American Journal of Clinical Medicine Research},
volume={2},
number={1},
pages={36--42},
year={2014},
url={http://pubs.sciepub.com/ajcmr/2/1/9},
issn={2328-403X},
abstract={<b>  </b><b>Objective</b><b>:</b><b> </b>Investigate the influence of permeability of low-flux versus high-flux dialysis membranes on intact PTH during hemodialysis. <b>Background</b><b>:</b> Hyperparathyroidism is a common finding in patients with renal insufficiency and parathyroid hormone (PTH) is considered a uremic toxin responsible for many of the abnormalities of the uremic state and bone disease. <b>Materials and Methods</b><b>:</b> Forty adult patients on regular hemodialysis were enrolled in a prospective study. Low-flux polysulfone membranes were used for at least 6 months and then the patients were switched to use high-flux polysulfone membranes for 1 month. Serum electrolytes and intact PTH before and after dialysis were compared before and after changes in dialysis membrane. <b>Results</b><b>:</b> At the end of the 1-month use of high-flux filters, predialysis intact PTH level (415.96 ¡À 226.72 ng/dL) showed a significant decline (P &lt; 0.05) compared to the predialysis intact PTH (312.28 ¡À 191.98 ng/dL) with low-flux membranes. Intact PTH level correlated negatively with serum calcium and positively with serum phosphorus levels only in the predialysis samples with the use of low-flux but not high-flux filters. <b>Conclusion</b><b>:</b> High-flux dialysis membranes are more efficient in removal of intact PTH, one of the middle-sized uremic toxins, than low-flux membranes.},
doi={10.12691/ajcmr-2-1-9}
publisher={Science and Education Publishing}
}