Science and Education Publishing American Journal of Clinical Medicine Research 2328-403X 2 1 2014 02 16 Study of Effect of High-Flux Versus Low-Flux Dialysis Membranes on Parathyroid Hormone 36 42 EN Ahmed Rabie El Arbagy Mahmoud Abd El Aziz Koura Abd El Samad Sobhy Abou El Nasr Hany Said Elbarbary Departments of Internal Medicine, Faculty of Medicine, Menoufia University, Menoufia, Egypt AJCMR2014219 10.12691/ajcmr-2-1-9 2014 01 23 2014 02 07 2014 02 16 Objective: Investigate the influence of permeability of low-flux versus high-flux dialysis membranes on intact PTH during hemodialysis. Background: Hyperparathyroidism is a common finding in patients with renal insufficiency and parathyroid hormone (PTH) is considered a uremic toxin responsible for many of the abnormalities of the uremic state and bone disease. Materials and Methods: Forty adult patients on regular hemodialysis were enrolled in a prospective study. Low-flux polysulfone membranes were used for at least 6 months and then the patients were switched to use high-flux polysulfone membranes for 1 month. Serum electrolytes and intact PTH before and after dialysis were compared before and after changes in dialysis membrane. Results: At the end of the 1-month use of high-flux filters, predialysis intact PTH level (415.96 ± 226.72 ng/dL) showed a significant decline (P < 0.05) compared to the predialysis intact PTH (312.28 ± 191.98 ng/dL) with low-flux membranes. Intact PTH level correlated negatively with serum calcium and positively with serum phosphorus levels only in the predialysis samples with the use of low-flux but not high-flux filters. Conclusion: High-flux dialysis membranes are more efficient in removal of intact PTH, one of the middle-sized uremic toxins, than low-flux membranes.