eng Science and Education Publishing American Journal of Clinical Medicine Research 2328-403X 2014-02-16 2 1 36 42 10.12691/ajcmr-2-1-9 AJCMR2014219 article Ahmed Rabie El Arbagy 1 Mahmoud Abd El Aziz Koura 1 Abd El Samad Sobhy Abou El Nasr 2 Hany Said Elbarbary hanyelbarbary2004@yahoo.com 2 Departments of Internal Medicine, Faculty of Medicine, Menoufia University, Menoufia, Egypt Internal Medicine Department, Benha teaching hospital, Qalyobia, Egypt Objective: Investigate the influence of permeability of low-flux versus high-flux dialysis membranes on intact PTH during hemodialysis. Background: Hyperparathyroidism is a common finding in patients with renal insufficiency and parathyroid hormone (PTH) is considered a uremic toxin responsible for many of the abnormalities of the uremic state and bone disease. Materials and Methods: Forty adult patients on regular hemodialysis were enrolled in a prospective study. Low-flux polysulfone membranes were used for at least 6 months and then the patients were switched to use high-flux polysulfone membranes for 1 month. Serum electrolytes and intact PTH before and after dialysis were compared before and after changes in dialysis membrane. Results: At the end of the 1-month use of high-flux filters, predialysis intact PTH level (415.96 ± 226.72 ng/dL) showed a significant decline (P < 0.05) compared to the predialysis intact PTH (312.28 ± 191.98 ng/dL) with low-flux membranes. Intact PTH level correlated negatively with serum calcium and positively with serum phosphorus levels only in the predialysis samples with the use of low-flux but not high-flux filters. Conclusion: High-flux dialysis membranes are more efficient in removal of intact PTH, one of the middle-sized uremic toxins, than low-flux membranes. http://pubs.sciepub.com/ajcmr/2/1/9/ajcmr-2-1-9.pdf Parathyroid hormoneESRDhemodialysis membrane