@article{ajcmr20221022,
author={{Fouzia, Hali and Amal, Kerouach and Sarah, Belanouane and Soumiya, Chiheb and Sofia, El Hadigui and Mounia, Diouri},
title={Melanoma Associated Leukoderma: Case Series and Literature Review},
journal={American Journal of Clinical Medicine Research},
volume={10},
number={2},
pages={36--41},
year={2022},
url={http://pubs.sciepub.com/ajcmr/10/2/2},
issn={2328-403X},
abstract={Vitiligo is an acquired achromia linked to an autoimmune destruction of melanocytes. One of its mysterious aspects is its occurrence with melanoma known as melanoma-associated leukoderma (MAL). The Objective of the study is to shed the light on the clinical aspects of MAL for a better understanding while providing a comprehensive review of the literature. We retrospectively analysed the clinical characteristics of 12 patients having MAL, from 2016-2021. We compared our findings to those reported in the literature. Our series illustrates different situations where vitiligo is linked to melanoma. None of our patients had a positive family history of vitiligo. The median age was 68 years with extremes of 90 and 36 years, 10 patients had their MAL located on photo-exposed areas. Clinically MAL presented as diffuse, macular achromic patches located primarly at sites distant from the primary melanoma and notably on the trunk, legs and face with a late age of onset. No histological particularities as opposed to vitiligo were found. Given the clinical similarities of these achromias with conventional vitiligo, a more thorough clinical examination for melanoma in patients with vitiligo seems to be crucial. Special attention is needed for older patients presenting with late onset, very progressive vitiligo-like lesions refractory to standard treatment.},
doi={10.12691/ajcmr-10-2-2}
publisher={Science and Education Publishing}
}