eng Science and Education Publishing American Journal of Clinical Medicine Research 2328-403X 2022-04-25 10 1 27 31 10.12691/ajcmr-10-1-6 AJCMR20221016 article Otike-Odibi Bolaji Bolajio_o@yahoo.com 1 Ujile Ichechiek 1 Department of Internal Medicine, Dermatology/Rheumatology Unit, University of Port Harcourt Teaching Hospital Background: Erythroderma is a rare, life threatening dermatological emergency with multiple underlying aetiologies. Methods: We reviewed the clinical, laboratory and histologic findings of 22 patients diagnosed with erythroderma, who were managed in the dermatology unit over six years (from 2016 to 2021). Results: Symptoms were scaly lesions, generalized rash, itching, fever, pustules, and on examination there was lichenification. The Male to Female ratio was 1.75:1 with a mean age at diagnosis of 41.6+17.3 years. The causative factors were commonly idiopathic (59 %) and drug-induced (9%). Others were psoriasis, lichen planus, and onchodermatitis. The comorbidities identified were HIV and Chronic kidney disease. Test of agreement between clinical and pathological diagnosis was 62.5%. Conclusion: Erythroderma is more common in men, aetiology was mostly idiopathic Test of agreement between clinical and pathological diagnosis was 62.5, showing biopsies are an important aid in making a definitive diagnosis. http://pubs.sciepub.com/ajcmr/10/1/6/ajcmr-10-1-6.pdf Erythroderma prevalence aetiology diagnostic accuracy